Close Menu

Georgia Papavasiliou, Ph.D.

Georgia Papavasiliou
Associate Professor of Biomedical Engineering

Office: 

3255 S Dearborn St., Wishnick Hall, Suite 314

Phone: 

312.567.5959

Fax: 

312.567.5707

Email: 

Education 

Post-Doctoral Internship, Johnson Polymer, 2003
Ph.D., Chemical Engineering, Illinois Institute of Technology, 2003
B.S., Chemical Engineering, Illinois Institute of Technology, 1996

Expertise 

Design, synthesis & characterization of hydrogel biomaterials; Cell biomaterial interactions; Polymer Reaction Engineering; Computational modeling of branched and crosslinked polymer systems; Tissue Engineering; Regenerative Medicine; Drug Delivery

Research 

Our research focuses on the coupling of computational modeling of polymerization and experimental design for the synthesis of hydrogel nanoparticle delivery vehicles and the synthetic hydrogel scaffolds for guiding cell behavior and tissue regeneration.

Current Research Projects

  • Development of hydrogel scaffolds with spatiotemporal biochemical and physical gradients for guided neovascularization
  • Design of proteolytically degradable hydrogel scaffolds with tunable degradation kinetics for tissue engineering applications
  • Fabrication of hydrogel nanoparticles for sustained delivery of angiogenic factors, therapeutic antimicrobial agents and small molecules for the treatment of disease
  • Sustained delivery of proangiogenic and vessel stabilizing peptide mimetic sequences for spatial and temporal delivery within scaffolds
  • Development of computational models of hydrogel formation for prediction and optimization of spatiotemporal biomaterial properties and biochemical composition

View related images

Research Funding

NIH R21 (HL094916-01A1) ERIF Pritzker Institute of Biomedical Science and Engineering

Awards 

IIT Research Fellow, 1996

AIChE Chicago Section McCormick Award Recipient, 1996

University Excellence in Teaching Award, IIT, 1998

W.M. Langdon Excellence in Chemical Engineering Teaching Award, IIT, 1998

University Excellence in Teaching Award-Illinois Institute of Technology, 2012

Tissue Engineering and Regenerative Medicine Society, 2nd Place Graduate Student Research Poster Competition, Houston Texas, December 2012

Books 

Book Chapters

Papavasiliou G, Teymour F. “Nonlinear Dynamics in Continuous Stirred Tank Reactor Polymerization.” In: Nonlinear Dynamics in Polymeric Systems. John A. Pojman and Qui Tran-Cong-Miyata (Editors), American Chemical Society, 2004, pp 309-323

Papavasiliou G, Sokic S, Turturro MV. Synthetic PEG Hydrogels as Extracellular Matrix Mimics for Tissue Engineering Applications. In: Biotechnology. Molecular Studies and Novel Applications for Improved Quality of Human Life,  Reda Sammour (Editor). InTech, ISBN: 979-953-307-738-2, 2012. doi: 10.5772/31695

Turturro MV and Papavasiliou G. Gradient Scaffolds for Vascularized Tissue Formation. In Vascularization: Regenerative Medicine and Tissue Engineering, Eric Brey (Editor). CRC Press, 2014, pp 163-189.

Professional Society Memberships 

Publications 

Peer Reviewed Publications

Papavasiliou G, Songprawat P, Pérez-Luna VH, Hammes EA, Morris M, and Brey EM. Three Dimensional Patterning in Poly(ethylene glycol) Hydrogels Through Surface Initiated Photopolymerization. Tissue Engineering Part C:  Methods. 14(2): 129-140, 2008.

Papavasiliou G, Cheng MH, Brey EM. Strategies for Vascularization of Polymer Scaffolds. Journal of Investigative Medicine. 58(7): 838-844, 2010. (Review Article)

Turturro MV, Papavasiliou G*. Generation of Mechanical and Biofunctional Gradients in PEG Diacrylate Hydrogels by Perfusion-Based Frontal Photopolymerization. Journal of Biomaterials Science Polymer Edition. 23(7): 917–939, 2012.

Sokic S, Papavasiliou G*. FGF-1 and Proteolytically-mediated Cleavage Site Presentation Influence 3D Fibroblast Invasion in Biomimetic PEGDA Hydrogels. Acta Biomaterialia. 8(6):2213-2222, 2012.

Sokic S, Papavasiliou G*. Controlled Proteolytic Cleavage Site Presentation in Biomimetic PEGDA Hydrogels Enhances Neovascularization In Vitro. Tissue Engineering Part A. 18(23-24):2477-2486, 2012.

Turturro MV, Vélez Rendón DM, Teymour F, Papavasiliou G. A Kinetic Investigation of PEG Hydrogel Formation via Perfusion Based Frontal Photopolymerization: Influence of Free Radical Polymerization Conditions on Frontal Velocity and Swelling Gradients. Macromolecular Reaction Engineering. 7(2): 107-115, 2013
(Featured in Cover)

Turturro MV, Sokic S, Larson JC and Papavasiliou G*. Effective Tuning of Ligand Incorporation and Mechanical Properties in Visible Light Photopolymerized Poly(ethylene glycol) Diacrylate Hydrogels Dictates Cell Adhesion and Proliferation. Biomedical Materials. 8(2): 25001-25012, 2013. (Featured Article)

Turturro MV, Christenson MC, Larson JC, Young DA, Brey EM, Papavasiliou G*. MMP-Sensitive PEG Diacrylate Hydrogels with Spatial Variations in Matrix Properties Stimulate Directional Vascular Sprout Formation. PLOS ONE. 8(3):e58897, 2013.

Lee C, Teymour F, Camastral H, Tirreli N, Hubbell JA, Elbert DL, Papavasiliou G*. Characterization of the Network Structure of PEG-diacrylate Hydrogels Formed in the Presence of Vinyl Pyrrolidone. Macromolecular Reaction Engineering. 8(4): 314-328, 2014.

Sokic S, Larson J, Larkin S, Papavasiliou G, Holmes T, Brey EM*. Label-Free Nondestructive Imaging of Vascular Network Structure in 3D Culture. Microvascular Research. 92: 72-78, 2014.

Sokic S, Christenson M, Larson J, Papavasiliou G*. In Situ Generation of Cell –Laden Porous MMP-Sensitive PEGDA Hydrogels by Gelatin Leaching. Macromolecular Bioscience. 14(5):731-739, 2014.

Sokic S, Appel A, Larson J, Christenson M, Brey E, and Papavasiliou G*.
Evaluation of  MMP Substrate Specificity and Concentration for Neovascularization of Hydrogel Scaffolds. Biomaterials Science. 2(10): 1343-1354, 2014. (Featured in Cover)

PhD Publications

Papavasiliou G, Teymour F. Bifurcation Analysis of Non-isothermal Nonlinear Polymerization. Industrial & Engineering Chemistry Research. 44(8): 2754-2766, 2005

Papavasiliou G, Teymour F. Reconstruction of the Chain Length Distribution for Vinyl Divinyl Copolymerization Using the Numerical Fractionation Technique. Macromolecular Theory & Simulations. 12(8): 543-548, 2003

Papavasiliou G, Birol I, Teymour F. Calculation of Molecular Weight Distributions in Non-linear Free-Radical Polymerization Using the Numerical Fractionation Technique. Macromolecular Theory and Simulations. 11(5): 533-548, 2002

Undergraduate Publications

Shao S, Papavasiliou G, and Arastoopour, H. Laser Doppler Anemometry (LDA) Diagnostics of the Two Phase Flow Parameters in a Liquid-Gas Two-Phase Flow System. AIChE Symposium Series, Advances in Fluidization and Fluid Particle Systems. 93( 317): 7-11, 1997.